Wednesday, January 27, 2016

methylglyoxal bacteria Manuka honey

Manuka honey

Manuka On MicrobiologyBytes I’ve often discussed dangerous antibiotic-resistant superbugs such as Staphylococcus aureus MRSA and Clostridium difficile, and what can be done about them. Manuka honey is gathered in New Zealand and Australia from bees which have fed on the manuka bush, Leptospermum scoparium. Recent research has shown that this particular honey has antibacterial activity due primarily to the presence of methylglyoxal (Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res. 2008 Apr;52(4):483-9). This substance originates from dihydroxyacetone, which is present in the nectar of manuka flowers in varying amounts (The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey. Carbohydr Res. 2009 May 26;344(8):1050-3). Nectar washed from manuka flowers contained high levels of dihydroxyacetone and no detectable methylglyoxal. Storage of manuka honey at 37°C leads to a decrease in the dihydroxyacetone content and a related increase in methylglyoxal. Addition of dihydroxyacetone to clover honey followed by incubation results in methylglyoxal levels similar to those found in manuka honey.
So why the fuss? Dressings containing manuka honey have been shown to be clinically effective against a wide range of bacteria which cause skin ulcers and chronic wound infections, a big problem in hospitals (PubMed: latest research). But manuka honey is in relatively short supply, and so expensive. Manuka honey is now being made in the UK from bushes brought to the Tregothnan Estate near Truro, Cornwall, in 1888. It goes well with a Cornish cream tea, but at £55 a pot, it’s still not cheap.
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    Story image for methylglyoxal from Phys.Org

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    2016 Marks 10 Years of Manuka Honey Science 18, 2016
    2016 marks 10 years since the compound methylglyoxal was discovered in manuka honey, a discovery that revolutionised the manuka honey ...

Story image for methylglyoxal from The Grocer
The Grocer

Methylglyoxal in Guidelines for Labelling Manuka Honey (press release)-Jul 30, 2014
New Zealand's Ministry for Primary Industries (MPI) has acknowledged methylglyoxal as being an allowable claim in labelling manuka honey.


Honey and its effect on MRSA and Other Natural Remedies
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New research has shown the honey kills every type of bacteria scientists have ... the honey, including superbugs such as flesh-eating bacteria, built up any immunity. She said a compound in the honey called methylglyoxal — toxic on its own ...
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It is applied externally and acts on skin infections, bites and cuts. ... to test the honey, including superbugs such as flesh-eating bacteria, built up any immunity. She said a compound in the honey called methylglyoxal -- toxic on 

Methylglyoxal - Wikipedia, the free encyclopedia
Methylglyoxal, also called pyruvaldehyde or 2-oxopropanal, is the organic compound with the formula CH3C(O)CHO. Gaseous methylglyoxal has two carbonyl groups, an aldehyde and a ketone but in the presence of water, it exists as hydrates and oligomers. It is a reduced derivative of pyruvic acid.

MGO Manuka Honey. What is Methylglyoxal?
Professor Thomas Henle of University of Dresden, Germany announced in 2008 that research "unambiguously demonstrates for the first time that Methylglyoxal ...
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Methylglyoxal—A Potential Risk Factor of Manuka Honey in ...
by J Majtan - ‎2010 - ‎Cited by 21 - ‎Related articles
Jan 31, 2010 - Recently, it has been documented that the pronounced antibacterial activity of manuka honey is due, at least in part, to reactive methylglyoxal (MG). The concentration of MG in manuka honeys is up to 100-fold higher than in conventional honeys.


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Sugar-derived methylglyoxal may damage 'good' cholesterol which helps protect against heart disease but protective proteins could counter ...
Sugar substance 'kills' good HDL cholesterol, new study finds
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